Signals Orchestrating Peripheral Nerve Repair
نویسندگان
چکیده
منابع مشابه
Peripheral nerve injury and repair.
Peripheral nerve injuries are common, and there is no easily available formula for successful treatment. Incomplete injuries are most frequent. Seddon classified nerve injuries into three categories: neurapraxia, axonotmesis, and neurotmesis. After complete axonal transection, the neuron undergoes a number of degenerative processes, followed by attempts at regeneration. A distal growth cone see...
متن کاملEngineered neural tissue for peripheral nerve repair.
A new combination of tissue engineering techniques provides a simple and effective method for building aligned cellular biomaterials. Self-alignment of Schwann cells within a tethered type-1 collagen matrix, followed by removal of interstitial fluid produces a stable tissue-like biomaterial that recreates the aligned cellular and extracellular matrix architecture associated with nerve grafts. S...
متن کاملTiming and technique of peripheral nerve repair.
Surgery of the peripheral nerves is briefly reviewed with special emphasis on the timing and the techniques of nerve repair. The sooner a severed nerve can be repaired, the better the quality of the recovery. While delays of a few months after injury appear to have no serious effect on the out come of nerve sutures, the chances of successful recovery decline after six months. It is not common f...
متن کاملThe effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair.
The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. Current clinically approved hollow nerve guidance conduits allow provision of this protective environment; however they fail to provide an essential internal architecture t...
متن کاملNanotechnology for peripheral nerve regeneration
Peripheral nerve injuries (PNI) can lead to lifetime loss of function and disfigurement. Different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. Designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and non-absorb...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells9081768